Patent · US Active

1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor

US10550091B2 · kind B2 · utility

0Cited by

1References

15Claims

0Family size

Assignee

St. Jude Children's Research Hospital, Inc. · US

Inventors

Taosheng Chen · Germantown, US
Wenwei Lin · Memphis, US
Yueming Wang · Hangzhou City, CN

Key dates

Filing date	Mar 10, 2017
Grant date	Feb 4, 2020
Priority date	—
Expiry date	Mar 10, 2037

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles, which are modulators the pregnane X receptor (“PXR”); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.