Third generation taxoids and methods of using same

US10550093B2 · kind B2 · utility

Assignee

• The Research Foundation for The State University of New York · US

Inventors

• Iwao Ojima · Port Jefferson, US
• Changwei Wang · Beijing, CN
• Xin Wang · Beijing, CN

Key dates

• Filing date: Jul 1, 2016
• Grant date: Feb 4, 2020
• Expiry date: Jul 1, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention includes taxoid compounds represented by the formula: wherein: R1 represents a methyl group or a fluorine; R2 represents an alkyl or alkenyl group having one to six carbon atoms; or a cycloalkyl or cycloalkenyl group having three to seven ring carbon atoms; R3 represents an alkyl, alkenyl, dialkylamino, alkylamino, or alkoxy group having one to six carbon atoms; a cycloalkyl or cycloalkenyl group having three to seven ring carbon atoms; an aryl group having six to eighteen ring carbon atoms; or a heteroaryl group having three to seventeen ring carbon atoms; R4 represents hydrogen or a methyl group; and X represents hydrogen or fluorine.