5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis
US10550100B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Jun 1, 2017 |
| Grant date | Feb 4, 2020 |
| Priority date | — |
| Expiry date | Jun 1, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention discloses compounds according to Formula I:Wherein R1, R2, R3a, R3b, R6, Cy, and the subscript n are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering the compound of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.