Tetrahydroquinoline sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR gamma (t))
US10550110B2 · kind B2 · utility
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Key dates
| Filing date | Dec 18, 2015 |
| Grant date | Feb 4, 2020 |
| Priority date | — |
| Expiry date | Jun 28, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Tetrahydroquinoline sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma (RORγt) are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of RORγt receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.