Patent · US Active

Methods for the preparation of obeticholic acid and derivatives thereof

US10550146B2 · kind B2 · utility

0Cited by

1References

20Claims

0Family size

Assignee

Intercept Pharmaceuticals, Inc. · US

Inventors

Benjamin List · Wetter (Ruhr), DE
Chandra Kanta DE · Mülheim an der Ruhr, DE
Qinggang Wang · Foshan, CN

Key dates

Filing date	Apr 18, 2017
Grant date	Feb 4, 2020
Priority date	—
Expiry date	Apr 18, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07J51/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present application relates to a safe method of preparing a bile acid derivative or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, on a large scale from 7-keto lithocholic acid (KLCA), comprising reacting Compound 2 with paraldehyde to form Compound 3 at a temperature between 10° C. and 30° C.:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.