Materials and methods for rapid and sensitive detection of small-molecule targets
US10550395B2 · kind B2 · utility
5Cited by
1References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 6, 2018 |
| Grant date | Feb 4, 2020 |
| Priority date | — |
| Expiry date | Apr 6, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/743
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The subject invention provides methods, assays and products for detecting small-molecules in a sample, in particular, in both clinical and field settings. The method for detecting a small-molecule target in a sample comprises providing a sample, contacting the sample with an aptamer-based sensor selective for the small-molecule target, and sensitively and rapidly detecting the small-molecule target in the sample. Specifically, the method utilizes EATR-amplified small-molecule sensors based on cooperative binding split aptamers (CBSAs).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.