System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US10551371B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 5, 2010 |
| Grant date | Feb 4, 2020 |
| Priority date | — |
| Expiry date | Nov 20, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/48735
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.