Highly penetrative nanocarriers for treatment of CNS disease
US10555911B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 6, 2013 |
| Grant date | Feb 11, 2020 |
| Priority date | — |
| Expiry date | May 6, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5153
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Brain-penetrating polymeric nanoparticles that can be loaded with drugs and are optimized for intracranial convection-enhanced delivery (CED) have been developed. In the preferred embodiment, these are loaded with FDA-approved compounds, identified through library screening to target brain cancer stem cells (BSCSs). The particles are formed by emulsifying a polymer-drug solution, then removing solvent and centrifuging at a first force to remove the larger particles, then collecting the smaller particles using a second higher force to sediment the smaller particles having a diameter of less than 100 nm, more preferably less than 90 nanometers average diameter, able to penetrate brain interstitial spaces.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.