Artificial antigen-presenting cells and methods for producing and using the same
US10556016B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 23, 2015 |
| Grant date | Feb 11, 2020 |
| Priority date | — |
| Expiry date | May 31, 2036 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.