Method for preparing Maraviroc
US10556899B2 · kind B2 · utility
0Cited by
6References
18Claims
0Family size
Assignee
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Key dates
| Filing date | Jan 25, 2019 |
| Grant date | Feb 11, 2020 |
| Priority date | — |
| Expiry date | Jan 25, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D451/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided is a method for preparing a tropane derivative, maraviroc, including reacting a compound of formula (II) with a compound of formula (I), wherein the compound of formula (II) is prepared by the steps of acetylation of a compound of formula (III), activation and substitution of a compound of formula (IV) by a chlorination agent, cyclization of a compound of formula (V), and debenzylation of a compound of formula (VI) by hydrogenation. Hence, the present disclosure provides a method for preparing maraviroc with good yield and simple operation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.