Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use

US10556914B2 · kind B2 · utility

Assignees

• Abb Vie Inc. · US
• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Jurgen Dinges · Wadsworth, US
• Achim Moeller · Grünstadt, DE
• Michael Ochse · Wiesbaden, DE
• Martin Schmidt · Frankfurt am Main, DE
• Michael Schulz · Jamestown, US
• Sean Turner · Ludwigshafen, DE
• Elizabeth Louise VAN DER KAM · Weesp, NL
• Anil Vasudevan · Union Grove, US

Key dates

• Filing date: May 10, 2019
• Grant date: Feb 11, 2020
• Expiry date: May 10, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the γ-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.