Synthetic artificial peptides with antimicrobial effect

US10556926B2 · kind B2 · utility

Assignee

• FRAUNHOFER-GESELSCHAFT · DE

Inventors

• Karsten Rapsch · Berlin, DE
• Markus v. Nickisch-Rosenegk · Großbeeren, DE

Key dates

• Filing date: Feb 9, 2015
• Grant date: Feb 11, 2020
• Expiry date: Feb 9, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to antimicrobial peptides of the general formula AxByCz with x, z≥1, y≥3 and x+y+z≤50, where A and C, in each case independently of one another, have at least 65% basic amino acids and B has at least 65% hydrophobic and/or nonpolar amino acids and comprises a direct sequence of at least three hydrophobic amino acids. Moreover, a medical use of the peptides, a conjugate and an antimicrobial composition are indicated.