Patent · US Active

Polypeptide libraries with a predetermined scaffold

US10556933B2 · kind B2 · utility

1Cited by

6References

20Claims

0Family size

Assignee

AFFIBODY AB · SE

Inventors

Lars Abrahmsen · Bromma, SE
Nina Herne · Stockholm, SE
Christofer Lendel · Älta, SE
Joachim Feldwisch · Tyresö, SE

Key dates

Filing date	Aug 16, 2016
Grant date	Feb 11, 2020
Priority date	—
Expiry date	Aug 24, 2037

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/31
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ (SEQ ID NO: 1) or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q (SEQ ID NO: 2), wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.