Method for purifying active polypeptides or immunoconjugates
US10556955B2 · kind B2 · utility
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14References
10Claims
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Key dates
| Filing date | Sep 7, 2018 |
| Grant date | Feb 11, 2020 |
| Priority date | — |
| Expiry date | Sep 7, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.