Patent · US Active

Chimeric antigen receptors with an optimized hinge region

US10556969B2 · kind B2 · utility

2Cited by

0References

8Claims

0Family size

Assignee

CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS · DE

Inventors

Kurt Schonfeld · Langen, DE
Christiane Schönfeld · Langen, DE
Winfried Wels · Emmendingen, DE

Key dates

Filing date	Oct 6, 2017
Grant date	Feb 11, 2020
Priority date	—
Expiry date	Oct 6, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human CD8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells. The proteins of the invention are chimeric antigen receptors with an optimized linker or hinge region that are suitable for generating target-specific effector cells, for use as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.