Patent · US Active

Gammadelta T cell expansion procedure

US10557117B2 · kind B2 · utility

1Cited by

0References

16Claims

0Family size

Assignee

KING'S COLLEGE LONDON · GB

Inventors

John Maher · London, GB
Ana Catarina PARENTE PEREIRA PURI · London, GB
Richard Esmond BEATSON · London, GB

Key dates

Filing date	Dec 4, 2015
Grant date	Feb 11, 2020
Priority date	—
Expiry date	Dec 11, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2506/11
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method for expanding a population of γδ T-cells is provided in which isolated activated Peripheral Blood Mononuclear Cells (PBMCs) are cultured in a medium comprising transforming growth factor beta (TGF-β) under conditions in which the production of effector γδ T-cells having therapeutic activity against malignant disease is favored. The use of TGF-β in the production of effector cells in particular Vγ9Vδ2 T-cells is also described and claimed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.