Biocompatible implantable sensor apparatus and methods
US10561353B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 1, 2016 |
| Grant date | Feb 18, 2020 |
| Priority date | — |
| Expiry date | Oct 29, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2310/00359
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Enzymatic and non-enzymatic detectors and associated membrane apparatus, and methods of use, such as within a fully implantable sensor apparatus. In one embodiment, detector performance is controlled through selective use of membrane configurations and enzyme region shapes, which enable accurate detection of blood glucose level within the solid tissue of the living host for extended periods of time. Isolation between the host's tissue and the underlying enzymes and reaction byproducts used in the detectors is also advantageously maintained in one embodiment via use of a non-enzyme containing permeable membrane formed of e.g., a biocompatible crosslinked protein-based material. Control of response range and/or rate in some embodiments also permits customization of sensor elements. In one variant, heterogeneous detector elements are used to, e.g., accommodate a wider range of blood glucose concentration within the host. Methods of manufacturing the membranes and detectors, including methods to increase reliability, are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.