Methods and devices for endovascular ablation of a splanchnic nerve

US10561461B2 · kind B2 · utility

Assignee

• AXON THERAPIES, INC. · US

Inventors

• Dorin Panescu · Sunnyvale, US
• Andrew Wu · Los Altos Hills, US
• Zoar Jacob Engelman · Salt Lake City, US
• Mark Gelfand · New York, US
• Mark S. Leung · Duncan, CA
• Howard R. Levin · Teaneck, US

Key dates

• Filing date: Dec 17, 2018
• Grant date: Feb 18, 2020
• Expiry date: Dec 17, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2025/1004
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.