Modified cell expansion and uses thereof
US10561686B2 · kind B2 · utility
11Cited by
2References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 28, 2018 |
| Grant date | Feb 18, 2020 |
| Priority date | — |
| Expiry date | Sep 28, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/75
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to compositions and methods for enhancing T cell response and/or CAR cell expansion in vivo and/or in vitro. For example, a cell may comprise a first chimeric antigen receptor (CAR) and a second CAR, wherein a binding domain of the first CAR binds a first antigen, and a binding domain of the second CAR binds a second antigen. The first antigen is different from the second antigen. In embodiments, the first CAR may recognize a surface molecule of a blood cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.