Trialkyl cationic lipids and methods of use thereof
US10561732B2 · kind B2 · utility
4Cited by
6References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 9, 2016 |
| Grant date | Feb 18, 2020 |
| Priority date | — |
| Expiry date | May 9, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.