Solid formulations of liquid biologically active agents
US10561735B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 20, 2017 |
| Grant date | Feb 18, 2020 |
| Priority date | — |
| Expiry date | Nov 20, 2037 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01F23/48
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.