Method for generating endothelial colony forming cell-like cells
US10563175B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Mar 11, 2015 |
| Grant date | Feb 18, 2020 |
| Priority date | — |
| Expiry date | May 15, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/54
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent cells into endothelial colony forming cell-like cells (ECFC-like cells) is provided. A purified human cell population of NRP-1+CD31+ ECFC-like cells is provided, wherein at least some of the cells in the population have a high proliferation potential. Therapeutic and test agent screening methods for using the cell populations of the present disclosure are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.