Cable movement-isolated multi-channel fluorescence measurement system
US10564101B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 2018 |
| Grant date | Feb 18, 2020 |
| Priority date | — |
| Expiry date | Nov 2, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/0853
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A multi-site fluorescence recording system provides simultaneous monitoring of cell activity in different brain regions of a freely moving animal. The system includes an electrical rotary joint that couples signals to and from an external data acquisition and control unit connected to a stator of the rotary joint, which releases twisting of the optical fibers connected to the animal. Electrical signals are coupled to one or more fluorescence stimulation/detection units on the rotor of the rotary joint. The fluorescence stimulation/detection units receive one or more connections from optical fibers that connect the stimulation/detection unit(s) to the different brain sites. The rotating stimulation/detection units include spectral filters to separate the excitation light from the fluorescence signal, light sensors (an image sensor or photodiodes) and excitation light sources.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.