Diffusion cell testing methods and system containing biphasic receptor fluids
US10564140B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 10, 2017 |
| Grant date | Feb 18, 2020 |
| Priority date | — |
| Expiry date | Apr 27, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2013/006
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An in vitro release testing method and system for testing the ability of formulations to deliver agents across a barrier membrane is disclosed. The method may comprise steps of providing a dosage of a semi-solid formulation containing the bioactive agent, a receptor solution, and a barrier membrane to separate the semi-solid formulation and the receptor solution. The receptor solution may be a biphasic solution or an immiscible solution. The semi-solid formulation may be contacted with one side of the barrier membrane and the receptor solution with the other side of the barrier membrane for a time sufficient to produce penetration of the barrier membrane by the semi-solid formulation. The receptor solution may be sampled and assayed to determine the concentration of the bioactive agent in the receptor solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.