RNAi molecule delivery platform based on single-siRNA and shRNA nanocapsules

US10568844B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Yunfeng Lu · Los Angeles, US
• Irvin S. Y. Chen · Rancho Palos Verdes, US
• Ming Yan · Los Angeles, US
• Min-Chang Liang · Baoshan, TW
• Masakazu Kamata · Los Angeles, US
• Jing Wen · Sudbury, US

Key dates

• Filing date: Sep 29, 2017
• Grant date: Feb 25, 2020
• Expiry date: Feb 11, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel siRNA and shRNA nanocapsules and delivery methods are disclosed herein. These siRNA and shRNA nanocapsules and delivery methods are highly robust and effective. This invention provides a platform for RNAi delivery with low toxicity and long intracellular half-life for practical therapeutic applications.