N-alkyl-2-phenoxyethanamines, their preparation and use

US10570148B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Konstantin Petrukhin · Collegeville, US
• Christopher Cioffi · Troy, US
• Graham Johnson · Madison, US
• Nicoleta Dobri · New York, US
• Emily Freeman · Voorheesville, US
• Ping Chen · Fujian, CN
• Michael Conlon · Albany, US
• Lei Zhu · Hefei, CN

Key dates

• Filing date: Apr 3, 2018
• Grant date: Feb 25, 2020
• Expiry date: Apr 3, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/052
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.