Patent · US Active

Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof

US10570191B2 · kind B2 · utility

5Cited by
5References
14Claims
0Family size

Assignee

Inventors

Key dates

Filing dateApr 15, 2016
Grant dateFeb 25, 2020
Priority date—
Expiry dateApr 15, 2036

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2740/16011
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

This disclosure provides a multimeric human immunodeficiency virus (HIV) protein binding molecule, e.g., an dimeric IgA or a pentameric or hexameric IgM binding molecule, comprising at least two bivalent binding units, or variants or fragments thereof, each comprising at least two antibody heavy chain constant regions or fragments thereof, wherein each heavy chain constant region or fragment thereof is associated with an HIV antigen binding domain. Also provided are compositions comprising the multimeric binding molecules, polynucleotides encoding the multimeric binding molecules, and methods to make and use the multimeric binding molecules.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.