Binding moieties for biofilm remediation

US10570193B2 · kind B2 · utility

Assignee

• Trellis Bioscience, Inc. · US

Inventors

• Lawrence M. Kauvar · San Francisco, US
• Stefan RYSER · Menlo Park, US
• Angeles Estelles · Belmont, US
• Reyna J. Simon · Felton, US
• Lauren O. Bakaletz · Hilliard, US
• Steven D. Goodman · Hilliard, US

Key dates

• Filing date: Nov 5, 2018
• Grant date: Feb 25, 2020
• Expiry date: Nov 5, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.