Nucleic acid modifying agents and uses thereof

US10570463B2 · kind B2 · utility

Assignee

• BIOTIUM, INC. · US

Inventors

• Fei Mao · Fremont, US
• Patrick Gordon McGarraugh · San Francisco, US
• Alexis Spain Madrid · Fremont, US
• Wai-Yee Leung · San Ramon, US
• Lori M. Roberts · Belmont, US

Key dates

• Filing date: Oct 29, 2015
• Grant date: Feb 25, 2020
• Expiry date: Jan 25, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2563/173
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In some aspects, the disclosure provides compounds comprising nucleic acid modifying moieties, such as nucleic acid binding dyes comprising activatable groups. In some aspects, the disclosure provides nucleic acid probes comprising compounds of the disclosure, and methods of making the same. In some aspects, the disclosure provides methods of using compounds of the disclosure, such as methods of labeling and/or detecting non-viable organisms or non-viable cells, and methods of detecting contamination or infection.