Low molecular weight cationic lipids for oligonucleotide delivery
US10576155B2 · kind B2 · utility
2Cited by
10References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 10, 2017 |
| Grant date | Mar 3, 2020 |
| Priority date | — |
| Expiry date | May 10, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention provides for novel catiome lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.