Use of ICOS-based CARS to enhance antitumor activity and CAR persistence
US10577407B2 · kind B2 · utility
1Cited by
34References
15Claims
0Family size
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Key dates
| Filing date | Jun 29, 2017 |
| Grant date | Mar 3, 2020 |
| Priority date | — |
| Expiry date | Jun 29, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/03
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.