Anti-plasmodium parasite antibodies

US10577412B2 · kind B2 · utility

Assignee

• Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V. · DE

Inventors

• Rolf Fendel · Aachen, DE
• Stefan Barth · Jena, DE
• Rainer Fischer · Monschau, DE
• Andreas Reimann · Krefeld, DE
• Dominika Maskus · Aachen, DE
• Torsten Klockenbring · Aachen, DE

Key dates

• Filing date: Apr 11, 2016
• Grant date: Mar 3, 2020
• Expiry date: May 21, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The technology provided herein relates to novel human antibodies against Plasmodium parasites, in particular against the malaria parasite Plasmodium falciparum. The present disclosure pertains to antibodies against apical membrane antigen 1 (AMA-1). These antibodies have high affinity e.g. to Plasmodium falciparum schizonts and merozoites, inhibit the reinvasion of merozoites into erythrocytes and thereby neutralize parasitic multiplication.