Process for the preparation of sugammadex

US10577433B2 · kind B2 · utility

Assignee

• Fresenius Kabi iPSUM S.r.l · IT

Inventors

• Walter Cabri · Sant Celoni, ES
• Antonio Ricci · Birsfelden, CH
• Jacopo Zanon · Venezia, IT
• Saswata Lahiri · Sindhar, IN
• Govind Singh · Ghaziabad, IN
• Shivaji Haribhau SHELKE · Jamkhed, IN
• Tapanjyoti Biswal · Barwala, IN
• Nitin Kumar · Delhi, IN
• Madan Singh · Port Aransas, US

Key dates

• Filing date: Mar 20, 2017
• Grant date: Mar 3, 2020
• Expiry date: Mar 20, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B37/0003
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6-per-halo-γ-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.