Enzyme scaffolds and methods of use
US10577633B2 · kind B2 · utility
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Key dates
| Filing date | Mar 23, 2017 |
| Grant date | Mar 3, 2020 |
| Priority date | — |
| Expiry date | Aug 3, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y202/01006
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Polypeptide scaffolds comprising enzymatic proteins are provided. The enzymatic polypeptide scaffolds comprise heterologous enzymes to form a heterologous metabolic pathway, and can be targeted to a substrate through a surface anchoring domain. The enzymatic polypeptide scaffolds leverage the high specificity and affinity protein/protein interaction between the cohesins and dockerins of microorganismal cellulosomes to form custom enzymatic arrays.
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