Peptide regulators of mitochondrial fusion and methods of use
US10578610B2 · kind B2 · utility
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Key dates
| Filing date | Sep 20, 2017 |
| Grant date | Mar 3, 2020 |
| Priority date | — |
| Expiry date | Sep 20, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2) and mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides for use in screening assays are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.