System and method for improved signal detection in NMR spectroscopy

US10578694B2 · kind B2 · utility

Assignee

• Bruker Biospin GmbH · DE

Inventors

• Christian Fischer · Waldbronn, DE
• Markus Lang · Munich, DE
• Martin Wyser · Regensdorf, CH
• Klaus-Peter Neidig · Ettlingen, DE
• Michael Fey · Andover, US

Key dates

• Filing date: Jun 18, 2019
• Grant date: Mar 3, 2020
• Expiry date: Jun 18, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/543
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Systems and methods for improved NMR signal detection are described. The system receives NMR signal data produced by a sample over time in response to an excitation pulse and selects a predefined system function for application to the NMR signal data for systematic variation of signal properties The system function has a different influence on NMR signal components than on noise components of the sampled signal and has a variation parameter to control the systematic variation. A plurality of variation parameter values is provided with differing values to influence broad NMR signals as well as weak NMR signals. The system generates for each variation parameter value a corresponding intermediate data set by applying the system function with the respective variation parameter value to the NMR signal data. Further, from each intermediate data set, a respective base value centered spectrum is generated in the frequency-domain.