Patent · US Active

Non-human animals having an engineered ANGPTL8 gene

US10582702B2 · kind B2 · utility

0Cited by

1References

16Claims

0Family size

Assignee

REGENERON PHARMACEUTICALS, INC. · US

Inventors

Viktoria Gusarova · Pleasantville, US
Andrew J. Murphy · Croton-on-Hudson, US
Jesper Gromada · Scarsdale, US
Dayong Guo · Beijing, CN

Key dates

Filing date	Feb 3, 2017
Grant date	Mar 10, 2020
Priority date	—
Expiry date	Feb 7, 2037

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/505
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an Angiopoietin-like protein 8 (ANGPTL8) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous ANGPTL8 locus so that said non-human animals express a human ANGPTL8 polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.