Patent · US Active

Liposomal formulations for delivery of nucleic acids

US10583084B2 · kind B2 · utility

4Cited by
78References
30Claims
0Family size

Assignee

Inventor

Key dates

Filing dateJun 25, 2015
Grant dateMar 10, 2020
Priority date—
Expiry dateJun 25, 2035

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2320/32
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

There are provided liposomes, comprising cationic lipids, a membrane stabilizing lipid and at least one lipid conjugated to a polyethylene glycol (PEG) derivative, in particular PEG-amine, the liposomes are coated with a glycosaminoglycan, in particular, Hyaluronic Acid (HA), compositions comprising the same, methods for their preparation and uses thereof for the efficient delivery of nucleic acids, such as, si RNA molecules and for treating various conditions, such as cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.