Vortex-induced silk fibroin gelation for encapsulation and delivery
US10583090B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 12, 2016 |
| Grant date | Mar 10, 2020 |
| Priority date | — |
| Expiry date | Jun 21, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provided for a novel process of forming silk fibroin gels, and controlling the rate of β-sheet formation and resulting hydrogelation kinetics, by vortex treatment of silk fibroin solution. In addition, the vortex treatment of the present invention provides a silk fibroin gel that may be reversibly shear-thinned, enabling the use of these approach for precise control of silk self-assembly, both spatially and temporally. Active agents, including biological materials, viable cells or therapeutic agents, can be encapsulated in the hydrogels formed from the processes, and be used as delivery vehicles. Hence, the present invention provide for methods for silk fibroin gelation that are useful for biotechnological applications such as encapsulation and delivery of active agents, cells, and bioactive molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.