Amphiphile-polymer particles

US10583091B2 · kind B2 · utility

Assignees

• The Brigham and Women's Hospital, Inc. · US
• President and Fellows of Harvard College · US

Inventors

• Jinjun Shi · San Jose, US
• Xi Zhu · 红钢城街道, CN
• Omid C. Farokhzad · Sharon, US
• Xiaoding Xu · Malden, US
• Yanlan Liu · Boston, US
• Aude Thiriot · Brookline, US
• Ulrich H. von Andrian · Sharon, US

Key dates

• Filing date: Oct 23, 2015
• Grant date: Mar 10, 2020
• Expiry date: Oct 23, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to amphiphile-polymer particles comprising obtaining a first solution comprising a water-insoluble polymer, a payload and a first amphiphile in a water-miscible solvent; mixing the first solution with an aqueous second solution to form an aqueous composition comprising a particle comprising a water-insoluble polymeric core comprising the water-insoluble polymer; the payload; and the first amphiphile.