Modulators of 14-3-3 functionality and uses thereof
US10583115B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 8, 2015 |
| Grant date | Mar 10, 2020 |
| Priority date | — |
| Expiry date | Oct 8, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to modulators of 14-3-3 functionality and their use in methods and compositions for preventing and/or treating various diseases, conditions and states, such as cancer and healing of wounds. Certain embodiments of the present disclosure provide a method of preventing and/or treating a disease, condition or state in a subject associated with altered 14-3-3 protein functionality and/or which would benefit from altering 14-3-3 functionality, the method comprising administering to the subject an effective amount of an agent which inhibits dimerization of the 14-3-3 protein, thereby preventing and/or treating the disease, condition or state in the subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.