Pulse dosing regimen and methods of treatment

US10583142B2 · kind B2 · utility

Assignee

• OSI Pharmaceuticals, LLC · US

Inventors

• Stanley C. Gill · Boulder, US
• Kenneth K. Iwata · Westbury, US
• Gregory J. Riely · New York, US
• Jun Wu · Vadnais Heights, US
• Helena Yu · New York, US

Key dates

• Filing date: Mar 25, 2016
• Grant date: Mar 10, 2020
• Expiry date: Mar 25, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel dosing regimen for erlotinib or a pharmaceutically acceptable salt thereof is described herein. The dosing regimen demonstrates impressive control of central nervous system disease, which is better than that reported with standard dose erlotinib. The use of the novel dosing regimen for treating patients in need thereof, including for controlling formation of metastatic brain, leptomeninges, or CNS lesions in a patient with non-small cell lung cancer (NSCLC) that harbors epidermal growth factor receptor (EGFR) mutation with or without pre-existing brain metastases, is also described herein.