Rapid-acting insulin formulation comprising a substituted anionic compound

US10583175B2 · kind B2 · utility

Assignee

• ADOCIA · FR

Inventors

• Olivier Soula · Meyzieu, FR
• Gerard Soula · Meyzieu, FR
• Emmanuel DAUTY · Val-de-Reuil, FR
• Richard Charvet · Rillieux-la-Pape, FR

Key dates

• Filing date: May 31, 2017
• Grant date: Mar 10, 2020
• Expiry date: May 31, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B37/0021
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A composition in aqueous solution includes insulin and at least one substituted anionic compound chosen from substituted anionic compounds consisting of a backbone formed from a discrete number u of between 1 and 8 (1≤u≤8) of identical or different saccharide units, linked via identical or different glycoside bonds, the saccharide units being chosen from the group consisting of hexoses, in cyclic form or in open reduced form, said compound comprising partially substituted carboxyl functional groups, the unsubstituted carboxyl functional groups being salifiable. A pharmaceutical formulation including the composition is also set forth.