Patent · US Active

Methods and compositions for immune protection against extra-intestinal pathogenic E. coli

US10583185B2 · kind B2 · utility

11Cited by

3References

20Claims

0Family size

Assignees

GLAXOSMITHKLINE BIOLOGICALS SA · BE
Janssen Pharmaceuticals, Inc. · BE

Inventors

Jan Poolman · Broek in Waterland, NL
Bert Jacquemyn · Mechelen, BE
Darren Robert ABBANAT · Towners, US
Patricia Ibarra Yon · Solothurn, CH
Peter Wilhelmus Maria Hermans · Huissen, NL
Michael Kowarik · Bellinzona, CH
Michael Wetter · Zürich, CH
Stefan Jochen KEMMLER · Schlieren, CH
Micha A. Häuptle · Zürich, CH
Veronica GAMBILLARA FONCK · Meilen, CH
Manuela Mally · Watt, CH

Key dates

Filing date	Aug 24, 2016
Grant date	Mar 10, 2020
Priority date	—
Expiry date	Sep 17, 2036

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.