Fluorination of acrylate esters and derivatives
US10584089B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 26, 2018 |
| Grant date | Mar 10, 2020 |
| Priority date | — |
| Expiry date | Nov 26, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C253/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent. In particular, a process for fluorinating a double bond is disclosed. This process comprises forming a reaction mixture comprising a hydrofluorocarbon solvent, fluorine gas, and a compound of formula 1 wherein R1 is hydroxy, alkoxy, chloro, or —OC(O)CH═CH2 to form a compound of formula 2 in a yield of at least 50% wherein R2 is hydroxy, alkoxy, chloro, —OC(O)CHFCH2F, wherein the hydrofluorocarbon solvent comprises 2H,3H-decafluoropentane and the reaction mixture further comprises a fluorination agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.