Methods of expanding hematopoietic stem cells, compositions, and methods of use thereof
US10584315B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Sep 23, 2016 |
| Grant date | Mar 10, 2020 |
| Priority date | — |
| Expiry date | Sep 23, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/60
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described herein are methods of expanding a population of hematopoietic stem cells by contacting the population of hematopoietic stem cells with an effective amount of an inhibitor of G-protein coupled receptor 65 (GPR65) and providing a population of expanded, substantially undifferentiated hematopoietic stem cells. Exemplary GPR65 inhibitors include siRNAs and certain sphingolipids. Also described are populations of expanded hematopoietic stem cells produced by the methods, media and kits containing GPR65 inhibitors, and methods for administering an expanded population of hematopoietic stem cells to patients.
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