Cell-based methods for measuring activity of a protein inhibitor
US10584369B2 · kind B2 · utility
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13Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 13, 2014 |
| Grant date | Mar 10, 2020 |
| Priority date | — |
| Expiry date | Apr 7, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/573
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides a method for determining the activity of an inhibitor of a target protein that has a deleterious effect on cell growth. The principle of the claimed method is that a compound that inhibits the function of an overexpressed protein will relieve the detrimental effect of such overexpression in a concentration-dependent manner, thereby allowing the determination of the activity of the compound in inhibiting its target protein in live cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.