Cooling liquid eluent of a carbon dioxide chromatography system after gas-liquid separation
US10585077B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 7, 2016 |
| Grant date | Mar 10, 2020 |
| Priority date | — |
| Expiry date | Feb 26, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/82
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as CO2, and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.