Non-cartesian retrospective reconstruction of cardiac motion in patients with severe arrhythmia

US10588511B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Francisco Contijoch · San Diego, US
• Walter R. T. Witschey · Philadelphia, US
• Robert C. Gorman · North Wales, US
• Yuchi Han · Philadelphia, US
• Joseph H. Gorman, III · North Wales, US

Key dates

• Filing date: Apr 24, 2015
• Grant date: Mar 17, 2020
• Expiry date: Mar 28, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/5611
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A retrospective reconstruction method uses cardiac self-gating for patients with severe arrhythmias. Self-gated myocardial systolic and diastolic motion is determined from low-spatial and high-temporal resolution images and then the MRI-dataset is retrospectively reconstructed to obtain high quality images. The method uses undersampled image reconstruction to obtain the low-spatial and high-temporal resolution images, including those of different beat morphologies. Processing of these images is utilized to generate a cardiac phase signal. This signal allows for arrhythmia detection and cardiac phase sorting. The cardiac phase signal allows for detection of end-systolic and diastolic events which allows for improved sampling efficiency. In the case of frequent and severe arrhythmia, the method utilizes data from the normal and interrupted beats to improve sampling and image quality.