Modulating antibacterial immunity via bacterial membrane-coated nanoparticles

US10588867B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Liangfang Zhang · San Diego, US
• Weiwei Gao · Village of La Jolla, US
• Ronnie H. Fang · San Diego, US
• Che-Ming Jack Hu · San Diego, US

Key dates

• Filing date: Jul 18, 2019
• Grant date: Mar 17, 2020
• Expiry date: Jul 18, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.